Chaga Mushroom Study’s

1. In 1960, the U.S. National Cancer Institute noted a report that a decoction of Chaga had been used successfully to treat cancer in Australia. Well known for stimulating the immune system, Chaga was approved for public use against cancer by the Medical Academy of Science in Moscow in 1955.

2. John Pezzuto of the University of Chicago is quoted as “the activity of the Betulinic acid is one of the most promising discoveries amongst 2500 plant extracts studied.” The Betulinic acid contained in Chaga covers the full spectrum of immune stimulating effects found in similar medicinal mushrooms such as Maitake and Shiitake mushrooms.

3. Russian and Japanese medical professionals both contend Chaga is many times more effective than Ganoderma Lucidum or Phellinus Linteus. The International Agriculture Development Institute in Korea confirms such claims.

4. The Japanese Cancer Society claims Chaga plays an important role in combating cancer and it jointly used with pharmacology drugs and chemotherapy diminishes their side effects.

5. “It is a fact that Chaga, placed into a birch bark casket, acquires more expressed therapeutic properties. Bioactive substances of the white part of birch bark having triterpenic bonds – betulin, lupeol, betulinic acid, etc. – possess anti-cancerous activity, causing apoptosis (programmed cell death) of cancerous cells and this is transfered to Chaga, thus strengthening its properties..”, says Galina Mikhaylovna Fedoseeva the Chairman of the Department of Pharmacognosy and Botany of Irkutsk State Medical University, professor, Doctor of the pharmaceutical sciences.

6. Numerous studies also indicate a 50% reduction in glycemic peaks are achieved due to the Beta Glucan effects on blood sugar levels. There are over 1000 research papers on Beta Glucan activity including studies from Harvard Medical School, National Cancer Institute, the Department of Agriculture and others. These studies prove Beta Glucan are external immunomodulators to keep one’s immune system in a highly prepared state.

Chaga Study

Korean J Nutr. 2007 Oct;40(7):601-605. Korean.
Effects of Inonotus Obliqua Extract on Blood Glucose Levels in Genetically Diabetic Mice.
Hong H. Hong H.
Department of Food Service Management and Nutrition, Sangmyung University, Seoul 110-743, Korea.

    This study investigated the therapeutic effects of Inonotus obliqua extract on blood glucose, insulin, and other biochemical parameters in genetically diabetic mice (C57BL/KsJ-m+/+Lepr(db)).

The mice were divided into four groups – control, Chaga 1 (dose of 0.09 mg/kg of body weight), Chaga 5 (5 times of Chaga 1), and Chaga 10 (10 times of Chaga 1)- according to supplemented dose.. Inonotus obliqua extract was orally administered to the animals for 6 weeks. The body and organ (liver and kidney) weights were not different among groups. Fasting blood glucose level was significantly lower in the Chaga 5 group compared with the control (p < 0.05). Hemoglobin A1c content was significantly lower in the Chaga 5 group compared with either the control and Chaga 1 group (p < 0.05). There was no significant difference in serum insulin level among groups. The glucose-6-phosphatase activity in liver was significantly the lowest in Chaga 10 group and was significantly lower in Chaga 5 group as compared with those of control and Chaga 1 groups. Therefore, the results of this study demonstrate that Inonotus obliqua extract alleviates many of the symptoms of diabetes in genetically obese mice and may offer a possibility as a therapeutic supplement for the normalization of blood glucose levels in human with hyperglycemia and have beneficial effects in patients with noninsulin-dependent diabetes mellitus.

Chaga Research

The post-antibiotic world of Western Medicine is now beginning to study, evaluate, and test Chaga for the active compounds underlying its historically understood homeopathic benefits. As with many other natural medicinal foods and herbs, the modern medical and scientific community is coming to understand that whole supplements like Chaga, offer a complex balance of active compounds, delivery mineral structures, and co-agents, more effective to sustaining a healthy immune balance than isolated compounds synthesized from these natural products.

The primary active compounds discovered in Siberian Chaga are a variety of triterpenes and sterols, including Lanosterol, Ergosterol Inotodials, Saponins, and Polysaccharides.Modern research is now beginning to demonstrate that these compounds are effective for human maladies treated by folk medicine practitioners with natural products, without toxic side-effect, for millennia.

After being ignored for hundreds of years by western pharmacologists, Chaga is currently enjoying a resurgence as a possible treatment for a wide variety of diseases and health problems, including chronic fatigue syndrome, the flu, stomach problems, and even HIV and certain types of cancer. Recent studies in the U.S., Russia, and other countries have shown Chaga to have anti-tumor benefits related to the mammary glands and female sex organs; studies in Finland have demonstrated that inotodial, one of the most active ingredients in Chaga, was effective against influenza virus and various cancer cells; and Japanese research not only found similar antiviral activity, but also discovered that Chaga shows activity against HIV (protease inhibition).

 Chaga has even been classified as a medicinal mushroom under World Trade Organization (WTO) codes. Arguably, the most well known western research conducted on the use of Chaga has been performed by Dr. Kirsti Kahlos and her team at School of Pharmacology, at the University of Helsinki, Finland. Dr. Kahlos’ team conducted studies validating the immuno-modulating impact of Lanosterol-linked triterpenes effective as a flu-vaccination and for anti-tumor applications. Institutional studies at the University of Tokyo, Japan have determined effectiveness of Inotodials in the destruction of certain carcinosarcomas and mammary adenocarcinomas.

The Melanin complex produced by the Chaga mushroom demonstrates high antioxidant and genoprotective effects ( Melanin Complex from Medicinal Mushroom Inonotus Obliquus, Journal of Medical Mushrooms, 2002, vol. 4) . The polysaccharide beta-glucan, also present in Chaga, is proven to be effective at inhibiting mutagenic and immuno-modulating effects of cancerous tumors by triggering immune system response (SP Wasser, 2002, Institute of Evolution, University of Haifa, Israel). In 1998 there was a study in Poland that demonstrated Chaga’s inhibiting effects on tumor growth.[1] Noda et. al found that betulin seems to work highly selectively on tumor cells because the interior pH of tumor tissues is generally lower than that of normal tissues, and betulinic acid is only active at those lower levels.Fulda et al. found in 1997 that once inside the cells, betulinic acid induces apoptosis (programmed cell death) in the tumors.[2] In 2005 there was a study done at Department of Medical Nutrition in South Korea.

The Chaga Mushroom was evaluated for their potential for protecting against oxidative damage to DNA in human lymphocytes. The study found that the polyphenolic extract protected these cells against hydrogen peroxide-induced oxidative stress.[3] Another study that year found the endo-polysaccharide of Chaga produced indirect anti-cancer effects via immuno-stimulation.The mycelial endo-polysaccharide of Inonotus Obliquus was identified as a candidate for use as an immune response modifier and indicates that the anti-cancer effect of endo-polysaccharide is not directly tumorcidal but rather is immuno-stimulating.[4][5] It has also been demonstrated as anti-inflammatory.[6] Saitoh Akiko published on the antimutagenic effects of Chaga in 1996, and Mizuno et al. published on the anti tumor and hypoglycemic activities of the polysaccharides from the sclerotia and mycelia of Chaga.

 The following article was published by the NCBI (National Center for Biotechnology Information) a joint venture by the National Library of Medicine and the National Institutes of Health.

Established in 1988 as a national resource for molecular biology information, NCBI creates public databases, conducts research in computational biology, develops software tools for analyzing genome data, and disseminates biomedical information – all for the better understanding of molecular processes affecting human health and disease. Chaga mushroom extract inhibits oxidative DNA damage in human lymphocytes as assessed by comet assay.The Chaga mushroom (Inonotus obliquus) is claimed to have beneficial properties for human health, such as anti-bacterial, anti-allergic, anti-inflammatory and antioxidant activities. The antioxidant effects of the mushroom may be partly explained by protection of cell components against free radicals. We evaluated the effect of aqueous Chaga mushroom extracts for their potential for protecting against oxidative damage to DNA in human lymphocytes. Cells were pretreated with various concentrations (10, 50, 100 and 500 microg/mL) of the extract for 1 h at 37 degrees C. Cells were then treated with 100 microM of H2O2 (Hydrogen Peroxide) for 5 min as an oxidative stress. Evaluation of oxidative damage was performed using single-cell gel electrophoresis for DNA fragmentation (Comet assay). Using image analysis, the degree of DNA damage was evaluated as the DNA tail moment.Cells pretreated with Chaga extract showed over 40% reduction in DNA fragmentation compared with the positive control (100 micromol H2O2 treatment). Thus, Chaga mushroom treatment affords cellular protection against endogenous DNA damage.

Chaga mushroom (Inonotus obliquus) induces G0/G1 arrest and apoptosis in human hepatoma HepG2 cells.

Vestibulocochlear Research Center, Wonkwang University School of Medicine, #344-2, Shinyoung-dong, Iksan, Jeonbuk 570-749, Korea.

AIM: To investigate the anti-proliferative and apoptotic effects of Chaga mushroom (Inonotus obliquus) water extract on human hepatoma cell lines, HepG2 and Hep3B cells. METHODS: The cytotoxicity of Chaga extract was screened by 3-[4,5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide (MTT) assay. Morphological observation, flow cytometry analysis, Western blot were employed to elucidate the cytotoxic mechanism of Chaga extract.

RESULTS: HepG2 cells were more sensitive to Chaga extract than Hep3B cells, as demonstrated by markedly reduced cell viability. Chaga extract inhibited the cell growth in a dose-dependent manner, which was accompanied with G0/G1-phase arrest and apoptotic cell death. In addition, G0/G1 arrest in the cell cycle was closely associated with down-regulation of p53, pRb, p27, cyclins D1, D2, E, cyclin-dependent kinase (Cdk) 2, Cdk4, and Cdk6 expression.

CONCLUSION: Chaga mushroom may provide a new therapeutic option, as a potential anticancer agent, in the treatment of hepatoma.

Source: www.pubmed.com

Wild Harvested Siberian Chaga Mushroom

(Inonotus Obliquus)

 Research Studies

 Anti – Aging

 Click here

Anti – Cancer / Tumor Metastasis

 Click here

 Click here

 Click here

 Anti – Fungal

Click here

 Anti – Inflamatory

 Click here

 Click here

 Click here

 Click here
Antioxidant / Genoprotective

 Click here
Click here

 Antioxidative Stress

 Click here

 Click here

 Anti – Tumor

Click here

Click here

Click here

Chemical Constituants

Click here

Oxidative DNA Damage / Protection

Click here

Genoprotective

Click here
Heart Cells

Click here
Immuno – Stimulator

Click here

Click here

Click here

Inhibit Cancer

Click here
Inhibit Cancer Cell Growth

Click here

Inhibit Tumor Growth

Click here

Leukemia

PDF – ADOBE DOCUMENT

Click here

Click here

Mushroom General Information

Click here

Mushrom Study Improvement

PDF – ADOBE DOCUMENT

Click here

Story of Chaga

PDF – ADOBE DOCUMENT

Click here

Web Article

Click here

Wikepedia Link

Click here

Chemical / Nutritional

Physical Properties

Beta-Glucan

Click here
Betulin or Betulinic Acid

Click here

Click here

Click here

Click here

Click here

Polysaccharides

Click here

 LANGUAGE  LINKS

 CHINA

 Link List

Click here

Click here

Click here

Ant-Oxidant

Click here

Gastric Carcinoma

Click here

FINLAND

Click here

Click here

 FRANCE

Click here

Click here

Click here

 POLAND

Click here

Click here

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s